Antimicrobial tolerance

Antimicrobial tolerance is the ability of bacteria to survive a normally lethal dose of antibiotics. This is exemplified  in biofilm infections. Supported by the Leenaards Prize, our group is establishing a highly translational research project with John McKinney of the EPFL and Beat Roth at CHUV/InselSpital to combat antibiotic tolerance in the context of infections of the urogenital tract.

• Targeting Antibiotic Tolerance, Pathogen by Pathogen.Meylan S, Andrews IW, Collins JJ. Cell. 2018 Mar 8;172(6):1228-1238. doi: 10.1016/j.cell.2018.01.037. PMID: 29522744. Voir l'article

• Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control. Meylan S, Porter CBM, Yang JH, Belenky P, Gutierrez A, Lobritz MA, Park J, Kim SH, Moskowitz SM, Collins JJ. Cell Chem Biol. 2017 Feb 16;24(2):195-206. doi: 10.1016/j.chembiol.2016.12.015. Epub 2017 Jan 19. PMID: 28111098. Voir l'article