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- Prof. Oriol MANUEL
- Covid-19 and other infectious complications
Prof. Oriol Manuel
Professeur associé
Médecin adjoint
Service des maladies infectieuses
Université de Lausanne (UNIL)
CHUV
BH10/549
Rue du Bugnon 46
1011 Lausanne, Suisse
Covid-19 and other infectious complications
The ongoing impact of Covid-19 on transplant recipients underscores the need for continued vigilance. Collaborating with all transplant programs at the CHUV, we have extensively documented the outcomes of Covid-19 across different variant eras [1,2]. We showed that outcomes of Covid-19 in this vulnerable population were better than previously published. We are currently collaborating in a randomized controlled trial of Covid-19 therapy for immunocompromised patients (Opticov trial, Pr Prof Calmy, Geneva).
During the initial pandemic wave, we contributed as the Swiss representative in the Solidarity trial, a large WHO-sponsored initiative evaluating Covid-19 therapies in hospitalized patients. We enrolled more than 250 patients in Switzerland and more than 14000 worldwide between 2020 and 2022. The Solidarity trial resulted in two high impact publications in the N Engl J Med and The Lancet [3,4].
Additionally, our research extends to other infectious complications post-transplant benefiting of the structure of the STCS. This includes the epidemiology and outcomes of bacterial food-borne infections [5], the impact of ECMO in infectious risk and mortality after heart transplantation (manuscript submitted), and the impact of the duration of antimicrobial prophylaxis with cotrimoxazole in the transplant settings.
Selected publications
Casutt A, Papadimitriou-Olivgeris M, Ioakeim F, Aubert JD, Manuel O, Koutsokera A. Transpl Infect Dis. 2023 Feb;25(1):e14007. doi: 10.1111/tid.14007. PMID: 36602439. View article
Papadimitriou-Olivgeris M, Cipriano A, Guggisberg N, Kroemer M, Tschopp J, Manuel O, Golshayan D. Transpl Int. 2022 Oct 4;35:10721. doi: 10.3389/ti.2022.10721. PMID: 36267693. View article
WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. PMID: 33264556. View article
WHO Solidarity Trial Consortium. Lancet. 2022 May 21;399(10339):1941-1953. doi: 10.1016/S0140-6736(22)00519-0. PMID: 35512728. View article
van den Bogaart L, Lang BM, Neofytos D, Egli A, Walti LN, Boggian K, Garzoni C, Berger C, Pascual M, van Delden C, Mueller NJ, Manuel O, Mombelli M; Swiss Transplant Cohort Study. Am J Transplant. 2022 Jan;22(1):199-209. doi: 10.1111/ajt.16831. PMID: 34514688. View article
Team
- Aline Munting, MD
- Lorena van den Bogaart, MD, Université de Lyon.
- Sophie Seydoux, MD student
- Valérie Sormani, RN
Open positions
- No current position available
Service des maladies infectieuses
Rue du Bugnon 46
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 1010
Service des maladies infectieuses
Rue du Bugnon 46
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 1010