Philippe Hauser Lab

Philippe Hauser, PhD, MER1, PD
Tel. +41 21 314 4084
Mobile: +41 78 870 6249
Contact mail

Research Topics

Pneumocystis jirovecii is a microscopic fungus causing severe pneumonia in immuno-compromised patients (AIDS, transplantation recipients, leukemia, etc.). In the absence of an in vitro culture system, the biology of this fungus remains poorly known.

Genomics of P. jirovecii

Thanks to recent technical developments, we have sequenced and are currently analyzing P. jirovecii genome (see Collaborative Research). Comparative genomics revealed the loss of specific pathways in Pneumocystis species. These findings strongly suggest that these fungi are obligate biotrophs of mammalian lungs, i.e. pathogens retrieving their nutriments without killing the cells of their host.

Antigenicity of P. jirovecii

We are studying the antigenic variation of P. jirovecii. This variation is based on the mutually exclusive expression of a family of genes located in the subtelomeres of the fungus's 20 chromosomes, as well as on the reassortment of these genes' repertoires and their mosaicism through genetic recombinations.

Mode of sexual reproduction of P. jirovecii

Comparative genomics were also used to investigate the mode of reproduction of P. jirovecii, a crucial feature since sexuality occurs within the host and appears obligatory. These analyses led to the working hypothesis that the mode of reproduction of Pneumocystis species is primary homothallism, i.e. that both sexes are present in each strain.