Laboratoire de dosages des médicaments
Besides diagnostics, the Laboratory of Clinical Pharmacology provides its expertise also for research support. We are dedicated to build bridges between basic pharmacology research with experimental models and applied clinical research and develop translational applications.
The LC-MS/MS Research Unit offers specialized expertise and performant instrumentations for sensitive analytical methods by liquid chromatography-tandem mass spectrometry (LC-MS/MS) applications, primarily supporting biomedical, clinical research, and diagnostic efforts. Our services are integrated within an ISO 15189:2022-accredited clinical laboratory, providing comprehensive support that includes state-of-the-art analytical method development and validation, data processing, and interpretation for clinical studies or routine diagnostic applications. Additionally, we assist research scientists in the adaptation and optimization of established clinical diagnostic protocols, facilitating their transition to latest generation LC-MS/MS platforms to enhance throughput, analytical quality, and turnaround time.
We provide access to LC-MS/MS systems, including the TSQ Altis and Quantis, for qualitative and quantitative analysis in human samples, in vitro studies, or animal models.
We have experience in various type of matrices including whole blood, plasma total and free (unbound) concentration, LCR, Dried blood Spot (DBS), Volumetric Absorptive Microsampling (VAMS) devices, human tissues biopsies, animal tissues, saliva, urine, cells (Peripheral Blood Mononuclear Cells (PBMCs), bacterias (incl. Mycobacteria)), Perfusion solution, etc.
Method validation file compliant with ISO 15189:2022 standard is available.
For further information, please contact us (see below).
- Therapeutic drug monitoring of JAK inhibitors as novel precision medicine instrument for acute and chronic inflammatory disorders, F Girardin, PI J Tachet, CHUV-University of Lausanne (SNF 10000892)
- Impact of extracorporeal membrane oxygenation (ECMO) on drug pharmacokinetics: review of ex vivo studies, analytical method development and validation, clinical study, and population pharmacokinetic modelling, F Livio PI, S Bertin, CHUV-University of Lausanne:
- Development of multiplex monitoring of levosimendan and its metabolites OR-1855 and OR-1896 in human plasma
- Model-based Meta Analysis Pharmacometric Approach to Characterize the Pharmacokinetics of Cytotoxic Chemotherapies for Precision Oncology, S Carrara, M Guidi, M Briki, CHUV- EPFL, Lausanne:
- Multiplex LC-MS/MS Quantification of 5-Fluorouracil and Its Metabolite 5,6-Dihydro-5-Fluorouracil with Metabolic Enzyme Phenotyping via Endogenous Uracil
- LC-MS/MS Quantification of Cyclophosphamide, Ifosfamide, Etoposide, Methotrexate and 7-Hydroxymethotrexate metabolite
- Development of a LC-MS/MS method for the analysis of next generation long-acting antiretrovirals (lenacapavir and islatravir) in plasma and application for their Therapeutic Drug Monitoring, L Decosterd, T Sono, CHUV- University of Geneva
- Real-life Therapeutic Drug Monitoring of CFTR modulators (caftors) in Cystic Fibrosis patients, an Observational Study, E Choong, S Blanchon, CHUV- University of Lausanne
- Development of an assay for the therapeutic drug monitoring of asparaginase in human plasma, E Choong, F Ceppi CHUV- University of Lausanne
- Role of anti-TB drug metabolism and cellular transport in the activity towards Mycobacterium tuberculosis; and: In vitro and in vivo characterization of functional consequences of bacterial metabolism and cellular transport of current, and investigational drugs against multidrug resistance tuberculosis, E Choong, O Opota, CHUV- University of Lausanne
PhD and master thesis
Pharmacists, Biologists, and Physicians can complete a Master or PhD thesis implying both a clinical project and a laboratory work at the bench. Scientists can perform their doctoral thesis at the Faculty of Biology and Medicine (FBM, UniL), at the Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO)- University of Geneva, and in collaboration with other academic institutions in Switzerland.
How to contact us
Rue du Bugnon 17
CHUV, Centre hospitalier universitaire vaudois
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 4260
Rue du Bugnon 17
CHUV, Centre hospitalier universitaire vaudois
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 4260