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- Pathologie clinique
- Notre équipe
- Pre Laurence de Leval
Pre Laurence de Leval
Professeure Laurence de Leval
Cheffe du Service de pathologie clinique
Institut universitaire de pathologie
Bugnon 25
CH-1011 Lausanne
Tél. +41 21 314 7194
Fax: +41 21 314 7115
Contact e-mail
Compétences
Formation
- Diplôme de Docteure en médecine, chirurgie et accouchement
- Spécialiste en Anatomie et cytologie pathologiques
- Spécialiste ISFM, pathologie
- Formation approfondie en pathologie moléculaire
Compétences spécifiques
- Hématopathologie
- Pathologie moléculaire
Langues
- Français, anglais
Publications
Follicular Helper T-cell Lymphoma With Hodgkin/Reed-Sternberg-Like Cells Versus Classic Hodgkin Lymphoma: A Comparative Study.
Petronilho S, Poullot E, Andre A, Robe C, Nouhoum S, Fataccioli V, Quintela JM, Claudel A, Brière J, Lechapt E, Lemonnier F, Henrique R, de Leval L, Gaulard P
Am J Surg Pathol. 2025 Mar 1;49(3):273-283
Efficacy of anti-PD1 therapy in extranodal NK/T cell lymphoma: A matched cohort analysis from the LYSA.
Marouf A, Chaubard S, Liévin R, Michot JM, Molinari N, Rossignol J, Cavalieri D, Golfier C, Allangba O, Philippe L, Tessoulin B, Chauchet A, Deau B, Oberic L, Vargaftig J, Moignet A, Clavert A, Dulery R, Brisou G, Tardy S, Fataccioli V, Houot R, Casasnovas RO, Thieblemont C, Ghesquières H, Carras S, Le Gouill S, Cartron G, Ribrag V, Cheminant M, Marçais A, Suarez F, Marabelle A, Tournilhac O, Damaj G, Gaulard P, De Leval L, Lemonnier F, Bachy E, Chevret S, Hermine O, Couronné L, Jaccard A
Hemasphere. 2025 Jan;9(1):e70081
Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targets.
Stephan P, Perrot J, Voisin A, Barbery M, Andrieu T, Grimont M, Caramel J, Bardou M, Tondeur G, Missiaglia E, Gaulard P, Lemmonier F, De Leval L, Bachy E, Sujobert P, Genestier L, Traverse-Glehen A, Grinberg-Bleyer Y
Haematologica. 2025 Jan 1;110(1):129-141
HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma.
Chantziou A, Brenna C, Ioannidou K, Chen OY, Korkolopoulou P, Antoniadou A, Psichogiou M, Papaioannou M, Tsirigotis P, Foukas PG, de Leval L, Petrovas C
Blood Adv. 2024 Dec 24;8(24):6215-6231
Long-Term Follow-Up of the Prospective Randomized AATT Study (Autologous or Allogeneic Transplantation in Patients With Peripheral T-Cell Lymphoma).
Tournilhac O, Altmann B, Friedrichs B, Bouabdallah K, Leclerc M, Cartron G, Turlure P, Reimer P, Wagner-Drouet E, Sanhes L, Houot R, Roussel M, Kroschinsky F, Dreger P, Viardot A, de Leval L, Rosenwald A, Gaulard P, Wulf G, Villate A, Latiere C, Elmaagacli A, Glass B, Poeschel V, Damaj G, Sibon D, Durot E, Bilger K, Banos A, Haenel M, Dreyling M, Keller U, Tiab M, Drenou B, Cornillon J, Nguyen S, Robin M, Nickelsen M, Trümper L, Lenz G, Ziepert M, Schmitz N, French Lymphoma Study Association (LYSA), the Société Francophone de greffe de moelle et Thérapie Cellulaire (SFGM-TC), and the German Lymphoma Alliance (GLA)
J Clin Oncol. 2024 Nov 10;42(32):3788-3794
Clinical use of circulating tumor DNA analysis in patients with lymphoma.
Bisig B, Lefort K, Carras S, de Leval L
Hum Pathol. 2024 Nov 2:105679
Hematological Oncology journal women in lymphoma special issue: Latest updates in nodal peripheral T-cell lymphoma.
Poon L, de Leval L, Ng SB, Song Y, Pro B, Savage KJ, Ruan J, Mehta-Shah N, Vose JM
Hematol Oncol. 2024 Nov;42(6):e3191
A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas.
de Leval L, Gaulard P, Dogan A
Blood. 2024 Oct 31;144(18):1855-1872
Modeling NK-cell lymphoma in mice reveals its cell-of-origin and microenvironmental changes and identifies therapeutic targets.
Koya J, Tanigawa T, Mizuno K, Kim H, Ito Y, Yuasa M, Yamaguchi K, Kogure Y, Saito Y, Shingaki S, Tabata M, Murakami K, Chiba K, Okada A, Shiraishi Y, Marouf A, Liévin R, Chaubard S, Jaccard A, Hermine O, de Leval L, Tournilhac O, Damaj G, Gaulard P, Couronné L, Yasui T, Nakashima K, Miyoshi H, Ohshima K, Kataoka K
Nat Commun. 2024 Oct 22;15(1):9106
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas.
Fischer A, Albert TK, Moreno N, Interlandi M, Mormann J, Glaser S, Patil P, de Faria FW, Richter M, Verma A, Balbach ST, Wagener R, Bens S, Dahlum S, Göbel C, Münter D, Inserte C, Graf M, Kremer E, Melcher V, Di Stefano G, Santi R, Chan A, Dogan A, Bush J, Hasselblatt M, Cheng S, Spetalen S, Fosså A, Hartmann W, Herbrüggen H, Robert S, Oyen F, Dugas M, Walter C, Sandmann S, Varghese J, Rossig C, Schüller U, Tzankov A, Pedersen MB, d'Amore FA, Mellgren K, Kontny U, Kancherla V, Veloza L, Missiaglia E, Fataccioli V, Gaulard P, Burkhardt B, Soehnlein O, Klapper W, de Leval L, Siebert R, Kerl K
Nat Commun. 2024 Oct 3;15(1):8571
Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue.
Sobottka B, Vetter V, Banaei-Esfahani A, Nowak M, Lorch A, Sirek A, Mertz KD, Brunelli M, Berthold D, de Leval L, Kahraman A, Koelzer VH, Moch H
Mod Pathol. 2024 Oct;37(10):100558
Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma.
Özoğul E, Montaner A, Pol M, Frigola G, Balagué O, Syrykh C, Bousquets-Muñoz P, Royo R, Fontaine J, Traverse-Glehen A, Bühler MM, Giudici L, Roncador M, Zenz T, Carras S, Valmary-Degano S, de Leval L, Bosch-Schips J, Climent F, Salmeron-Villalobos J, Bashiri M, Ruiz-Gaspà S, Costa D, Beà S, Salaverria I, Giné E, Quintanilla-Martinez L, Brousset P, Raffeld M, Jaffe ES, Puente XS, López C, Nadeu F, Campo E
Blood Cancer J. 2024 Sep 23;14(1):166
Inducible CXCL12/CXCR4-dependent extramedullary hematopoietic niches in the adrenal gland.
Schyrr F, Alonso-Calleja A, Vijaykumar A, Sordet-Dessimoz J, Gebhard S, Sarkis R, Bataclan C, Ferreira Lopes S, Oggier A, de Leval L, Nombela-Arrieta C, Naveiras O
Blood. 2024 Aug 29;144(9):964-976
Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells.
Moysi E, Sharma AA, O'Dell S, Georgakis S, Del Rio Estrada PM, Torres-Ruiz F, Navarro MG, Villalobos YAL, Rios SA, Reyes-Teran G, Beddall MH, Ko SH, Belinky F, Orfanakis M, de Leval L, Enriquez AB, Buckner CM, Moir S, Doria-Rose N, Boritz E, Mascola JR, Sekaly RP, Koup RA, Petrovas C
bioRxiv. 2024 Aug 3
Primary diffuse large B-cell lymphoma of the central nervous system identified with CSF biomarkers.
Loser V, Segot A, de Leval L, Bisig B, Brouland JP, Hewer E, Barcena C, Hottinger AF, Pot C
BMC Neurol. 2024 Jul 22;24(1):250
Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma.
Ito Y, Marouf A, Kogure Y, Koya J, Liévin R, Bruneau J, Tabata M, Saito Y, Shingaki S, Yuasa M, Yamaguchi K, Murakami K, Weil R, Vavasseur M, Andrieu GP, Latiri M, Veleanu L, Dussiot M, André I, Joshi A, Lagresle-Peyrou C, Magerus A, Chaubard S, Lavergne D, Bachy E, Brunet E, Fataccioli V, Brouzes C, Laurent C, de Leval L, Traverse-Glehen A, Bossard C, Parrens M, Meignin V, Philippe L, Rossignol J, Suarez F, Michot JM, Tournilhac O, Damaj G, Lemonnier F, Bôle-Feysot C, Nitschké P, Tesson B, Laurent C, Molina T, Asnafi V, Watatani Y, Chiba K, Okada A, Shiraishi Y, Tsukita S, Izutsu K, Miyoshi H, Ohshima K, Sakata S, Dobashi A, Takeuchi K, Sanada M, Gaulard P, Jaccard A, Ogawa S, Hermine O, Kataoka K, Couronné L
Cancer Res. 2024 Jul 2;84(13):2181-2201
[Aplastic anemia].
Dewarrat N, Costanza M, Royer-Chardon C, Zermatten MG, De Leval L, Naveiras O, Blum S
Rev Med Suisse. 2024 Jun 26;20(880):1271-1275
PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.
Chmiest D, Podavini S, Ioannidou K, Vallois D, Décaillet C, Gonzalez M, Quadroni M, Blackney K, Schairer R, de Leval L, Thome M
Blood Adv. 2024 Jun 11;8(11):2908-2923
Oral azacitidine compared with standard therapy in patients with relapsed or refractory follicular helper T-cell lymphoma (ORACLE): an open-label randomised, phase 3 study.
Dupuis J, Bachy E, Morschhauser F, Cartron G, Fukuhara N, Daguindau N, Casasnovas RO, Snauwaert S, Gressin R, Fox CP, d'Amore FA, Staber PB, Tournilhac O, Bouabdallah K, Thieblemont C, André M, Rai S, Ennishi D, Gkasiamis A, Nishio M, Fornecker LM, Delfau-Larue MH, Sako N, Mule S, de Leval L, Gaulard P, Tsukasaki K, Lemonnier F
Lancet Haematol. 2024 Jun;11(6):e406-e414
Romidepsin Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Versus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-CHOP Trial.
Camus V, Thieblemont C, Gaulard P, Cheminant M, Casasnovas RO, Ysebaert L, Damaj GL, Guidez S, Pica GM, Kim WS, Lim ST, Andre M, Gutiérrez N, Penarrubia MJ, Staber PB, Trotman J, Hüttmann A, Stefoni V, Tucci A, Fogarty P, Farhat H, Abraham J, Abarah W, Belmecheri F, Ribrag V, Delfau-Larue MH, Cottereau AS, Itti E, Li J, Delarue R, de Leval L, Morschhauser F, Bachy E
J Clin Oncol. 2024 May 10;42(14):1612-1618
Cytokine-pathway blockers worsen mycosis fungoides masquerading as psoriasis.
Blanchard G, Bisig B, de Leval L, Hohl D, Guenova E
JAAD Case Rep. 2024 Jun;48:98-102
Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases.
Sarro R, Bisig B, Guey B, Missiaglia E, Cairoli A, Omoumi P, Letovanec I, Ferry JA, Hasserjian RP, de Leval L
Mod Pathol. 2024 Apr;37(4):100440
Erratum to: Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization.
Savage KJ, De Leval L
Haematologica. 2024 Feb 1;109(2):693-694
Angioimmunoblastic T-cell lymphoma and Kaposi sarcoma: A fortuitous collision?
Poullot E, Milowich D, Lemonnier F, Bisig B, Robe C, Pelletier L, Letourneau A, Dupuy A, Sako N, Ketterer N, Carde P, Dartigues P, Delfau-Larue MH, de Leval L, Gaulard P
Histopathology. 2024 Feb;84(3):556-564
What is new in the classification of peripheral T cell lymphomas?
de Leval L, Bisig B
Pathologie (Heidelb). 2023 Dec;44(Suppl 3):128-135
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions.
Bisig B, Savage KJ, De Leval L
Haematologica. 2023 Dec 1;108(12):3227-3243
B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L, Fadle N, Regitz E, Roth S, Cetin O, Kos IA, Hess SM, Bein J, Bohle RM, Vornanen M, Sundström C, De Leval L, Tiacci E, Borchmann P, Engert A, Poeschel V, Held G, Schwarz EC, Neumann F, Preuss KD, Hoth M, Küppers R, Lehman K, Hansmann ML, Becker SL, Bewarder M, Hartmann S
Haematologica. 2023 Dec 1;108(12):3347-3358
Invariant finding of non-clonal bone marrow lymphocytosis, with increased B cell component, in indolent systemic mastocytosis.
Papadopoulou V, Barcena-Garcia C, Basset V, Schoumans J, de Leval L, Schaller M
Int J Lab Hematol. 2023 Dec;45(6):1007-1010
Introduction to the peripheral T-cell lymphoma review series: advances in molecular characterization, classification refinement and treatment optimization.
Savage KJ, De Leval L
Haematologica. 2023 Dec 1;108(12):3204-3210
Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio.
Straub M, Auderset A, de Leval L, Piazzon N, Maison D, Vozenin MC, Ollivier J, Petit B, Sigman DM, Martínez-García A
Sci Rep. 2023 Nov 13;13(1):19796
KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma.
Decroos A, Cheminant M, Bruneau J, Carras S, Parinet V, Pelletier L, Lacroix L, Martin N, Giustiniani J, Lhermitte L, Asnafi V, Battistella M, Lemonnier F, De Leval L, Sicard H, Bonnafous C, Gauthier L, Genestier L, Caruso S, Gaulard P, Hermine O, Ortonne N
Haematologica. 2023 Oct 1;108(10):2830-2836
Correction to: Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.
Di Napoli A, Soma L, Quintanilla-Martinez L, de Leval L, Leoncini L, Zamò A, Ng SB, Ondrejka SL, Climent F, Wotherspoon A, Dirnhofer S
Virchows Arch. 2023 Sep;483(3):435
Correction to: The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Zamò A, van den Brand M, Climent F, de Leval L, Dirnhofer S, Leoncini L, Ng SB, Ondrejka SL, Quintanilla-Martinez L, Soma L, Wotherspoon A
Virchows Arch. 2023 Sep;483(3):437
Follicular helper T-cell lymphomas: disease spectrum, relationship with clonal hematopoiesis, and mimics. A report of the 2022 EA4HP/SH lymphoma workshop.
Ondrejka SL, Amador C, Climent F, Ng SB, Soma L, Zamo A, Dirnhofer S, Quintanilla-Martinez L, Wotherspoon A, Leoncini L, de Leval L
Virchows Arch. 2023 Sep;483(3):349-365
Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch. 2023 Sep;483(3):281-298
Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop.
Di Napoli A, Soma L, Quintanilla-Martinez L, de Leval L, Leoncini L, Zamò A, Ng SB, Ondrejka SL, Climent F, Wotherspoon A, Dirnhofer S
Virchows Arch. 2023 Sep;483(3):299-316
Cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases: emerging concepts, recent advances, and the putative role of clonal hematopoiesis. A report of the 2022 EA4HP/SH lymphoma workshop.
Climent F, Nicolae A, de Leval L, Dirnhofer S, Leoncini L, Ondrejka SL, Soma L, Wotherspoon A, Zamo A, Quintanilla-Martinez L, Ng SB
Virchows Arch. 2023 Sep;483(3):333-348
The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Zamò A, van den Brand M, Climent F, de Leval L, Dirnhofer S, Leoncini L, Ng SB, Ondrejka SL, Quintanilla-Martinez L, Soma L, Wotherspoon A
Virchows Arch. 2023 Sep;483(3):317-331
A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells.
Joo V, Petrovas C, de Leval L, Noto A, Obeid M, Fenwick C, Pantaleo G
Front Immunol. 2023;14:1213375
Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches.
Oyler BL, Valencia-Dávila JA, Moysi E, Molyvdas A, Ioannidou K, March K, Ambrozak D, De Leval L, Fabozzi G, Woods AS, Koup RA, Petrovas C
iScience. 2023 Aug 18;26(8):107261
ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.
Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica. 2023 Jun 1;108(6):1590-1603
MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology.
Sarkis R, Burri O, Royer-Chardon C, Schyrr F, Blum S, Costanza M, Cherix S, Piazzon N, Barcena C, Bisig B, Nardi V, Sarro R, Ambrosini G, Weigert M, Spertini O, Blum S, Deplancke B, Seitz A, de Leval L, Naveiras O
Mod Pathol. 2023 Apr;36(4):100088
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment.
Leca J, Lemonnier F, Meydan C, Foox J, El Ghamrasni S, Mboumba DL, Duncan GS, Fortin J, Sakamoto T, Tobin C, Hodgson K, Haight J, Smith LK, Elia AJ, Butler D, Berger T, de Leval L, Mason CE, Melnick A, Gaulard P, Mak TW
Cancer Cell. 2023 Feb 13;41(2):323-339.e10
Combined Reverse-Transcriptase Multiplex Ligation-Dependent Probe Amplification and Next-Generation Sequencing Analyses to Assign Unclassified BCL2(-)/BCL6(-) Nonrearranged Small B-Cell Lymphoid Neoplasms as Follicular or Nodal Marginal Zone Lymphoma.
Sesboue C, Galtier J, Jeanneau M, Chauvel A, Laharanne E, Amintas S, Merlio JP, Bouabdallah K, Gros FX, de Leval L, Gros A, Parrens M
Mod Pathol. 2023 Feb;36(2):100043
Extranodal T- and NK-cell lymphomas.
de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch. 2023 Jan;482(1):245-264
Classification and diagnostic evaluation of nodal T- and NK-cell lymphomas.
Feldman AL, Laurent C, Narbaitz M, Nakamura S, Chan WC, de Leval L, Gaulard P
Virchows Arch. 2023 Jan;482(1):265-279
Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.
Veloza L, Cavalieri D, Missiaglia E, Ledoux-Pilon A, Bisig B, Pereira B, Bonnet C, Poullot E, Quintanilla-Martinez L, Dubois R, Llamas-Gutierrez F, Bossard C, De Wind R, Drieux F, Fontaine J, Parrens M, Sandrini J, Fataccioli V, Delfau-Larue MH, Daniel A, Lhomme F, Clément-Filliatre L, Lemonnier F, Cairoli A, Morel P, Glaisner S, Joly B, El Yamani A, Laribi K, Bachy E, Siebert R, Vallois D, Gaulard P, Tournilhac O, De Leval L
Haematologica. 2023 Jan 1;108(1):181-195
HHV8-negative primary effusion-based large B-cell lymphoma in a patient with chronic myeloid leukemia, BCR::ABL1-positive under dasatinib treatment: Report of a new case and literature review.
Christe L, Veloza L, Gros L, Bisig B, Blum S, Hewer E, de Leval L
Diagn Cytopathol. 2022 Dec;50(12):E351-E356
Genomic profiling for clinical decision making in lymphoid neoplasms.
de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies A, Dogan A, Fitzgibbon J, Horwitz SM, Melnick AM, Morice WG, Morin RD, Nadel B, Pileri SA, Rosenquist R, Rossi D, Salaverria I, Steidl C, Treon SP, Zelenetz AD, Advani RH, Allen CE, Ansell SM, Chan WC, Cook JR, Cook LB, d'Amore F, Dirnhofer S, Dreyling M, Dunleavy K, Feldman AL, Fend F, Gaulard P, Ghia P, Gribben JG, Hermine O, Hodson DJ, Hsi ED, Inghirami G, Jaffe ES, Karube K, Kataoka K, Klapper W, Kim WS, King RL, Ko YH, LaCasce AS, Lenz G, Martin-Subero JI, Piris MA, Pittaluga S, Pasqualucci L, Quintanilla-Martinez L, Rodig SJ, Rosenwald A, Salles GA, San-Miguel J, Savage KJ, Sehn LH, Semenzato G, Staudt LM, Swerdlow SH, Tam CS, Trotman J, Vose JM, Weigert O, Wilson WH, Winter JN, Wu CJ, Zinzani PL, Zucca E, Bagg A, Scott DW
Blood. 2022 Nov 24;140(21):2193-2227
Towards a national strategy for digital pathology in Switzerland.
Janowczyk A, Baumhoer D, Dirnhofer S, Grobholz R, Kipar A, de Leval L, Merkler D, Michielin O, Moch H, Perren A, Rottenberg S, Rubbia-Brandt L, Rubin MA, Sempoux C, Tolnay M, Zlobec I, Koelzer VH, Swiss Digital Pathology Consortium (SDiPath)
Virchows Arch. 2022 Oct;481(4):647-652
Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.
Bisig B, Cairoli A, Gaide O, Somja J, Bregnard C, Gaulard P, Xerri L, Lefort K, Missiaglia E, Gilliet M, Hohl D, Guenova E, de Leval L
Virchows Arch. 2022 Oct;481(4):653-657
The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee.
Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, Brousset P, Cerroni L, de Leval L, Dirnhofer S, Dogan A, Feldman AL, Fend F, Friedberg JW, Gaulard P, Ghia P, Horwitz SM, King RL, Salles G, San-Miguel J, Seymour JF, Treon SP, Vose JM, Zucca E, Advani R, Ansell S, Au WY, Barrionuevo C, Bergsagel L, Chan WC, Cohen JI, d'Amore F, Davies A, Falini B, Ghobrial IM, Goodlad JR, Gribben JG, Hsi ED, Kahl BS, Kim WS, Kumar S, LaCasce AS, Laurent C, Lenz G, Leonard JP, Link MP, Lopez-Guillermo A, Mateos MV, Macintyre E, Melnick AM, Morschhauser F, Nakamura S, Narbaitz M, Pavlovsky A, Pileri SA, Piris M, Pro B, Rajkumar V, Rosen ST, Sander B, Sehn L, Shipp MA, Smith SM, Staudt LM, Thieblemont C, Tousseyn T, Wilson WH, Yoshino T, Zinzani PL, Dreyling M, Scott DW, Winter JN, Zelenetz AD
Blood. 2022 Sep 15;140(11):1229-1253
EBV-associated NK and T-cell lymphoid neoplasms.
Kimura H, de Leval L, Cai Q, Kim WS
Curr Opin Oncol. 2022 Sep 1;34(5):422-431
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.
Evangelou K, Veroutis D, Paschalaki K, Foukas PG, Lagopati N, Dimitriou M, Papaspyropoulos A, Konda B, Hazapis O, Polyzou A, Havaki S, Kotsinas A, Kittas C, Tzioufas AG, de Leval L, Vassilakos D, Tsiodras S, Stripp BR, Papantonis A, Blandino G, Karakasiliotis I, Barnes PJ, Gorgoulis VG
Eur Respir J. 2022 Aug;60(2)
Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations.
Nicolae A, Bouilly J, Lara D, Fataccioli V, Lemonnier F, Drieux F, Parrens M, Robe C, Poullot E, Bisig B, Bossard C, Letourneau A, Missiaglia E, Bonnet C, Szablewski V, Traverse-Glehen A, Delfau-Larue MH, de Leval L, Gaulard P
Mod Pathol. 2022 Aug;35(8):1126-1136
The EHA Research Roadmap: Malignant Lymphoid Diseases.
Dreyling M, André M, Gökbuget N, Tilly H, Jerkeman M, Gribben J, Ferreri A, Morel P, Stilgenbauer S, Fox C, Maria Ribera J, Zweegman S, Aurer I, Bödör C, Burkhardt B, Buske C, Dollores Caballero M, Campo E, Chapuy B, Davies A, de Leval L, Doorduijn J, Federico M, Gaulard P, Gay F, Ghia P, Grønbæk K, Goldschmidt H, Kersten MJ, Kiesewetter B, Landman-Parker J, Le Gouill S, Lenz G, Leppä S, Lopez-Guillermo A, Macintyre E, Mantega MVM, Moreau P, Moreno C, Nadel B, Okosun J, Owen R, Pospisilova S, Pott C, Robak T, Spina M, Stamatopoulos K, Stary J, Tarte K, Tedeschi A, Thieblemont C, Trappe RU, Trümper LH, Salles G
Hemasphere. 2022 Jun;6(6):e726
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
Wu W, Nelson GM, Koch R, Donovan KA, Nowak RP, Heavican-Foral TB, Nirmal AJ, Liu H, Yang L, Duffy J, Powers F, Stevenson KE, Jones MK, Ng SY, Wu G, Jain S, Xu R, Amaka S, Trevisani C, Donaldson NL, Hagner PR, de Leval L, Gaulard P, Iqbal J, Thakurta A, Fischer ES, Adelman K, Weinstock DM
Blood. 2022 Mar 31;139(13):2024-2037
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A
Nature. 2022 Mar;603(7899):145-151
EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disor
Veloza L, Tsai CY, Bisig B, Pantet O, Alberio L, Sempoux C, Cavassini M, de Leval L
Virchows Arch. 2022 Mar;480(3):699-705
Venetoclax combined with FLAG-based chemotherapy induces an early and deep response in mixed-phenotype-acute leukemia.
Ségot A, Stalder G, de Leval L, Solly F, Schoumans J, Basset V, Blum S, Spertini O
Am J Hematol. 2022 Mar 1;97(3):E91-E93
Genetic and phenotypic attributes of splenic marginal zone lymphoma.
Bonfiglio F, Bruscaggin A, Guidetti F, Terzi di Bergamo L, Faderl M, Spina V, Condoluci A, Bonomini L, Forestieri G, Koch R, Piffaretti D, Pini K, Pirosa MC, Cittone MG, Arribas A, Lucioni M, Ghilardi G, Wu W, Arcaini L, Baptista MJ, Bastidas G, Bea S, Boldorini R, Broccoli A, Buehler MM, Canzonieri V, Cascione L, Ceriani L, Cogliatti S, Corradini P, Derenzini E, Devizzi L, Dietrich S, Elia AR, Facchetti F, Gaidano G, Garcia JF, Gerber B, Ghia P, Gomes da Silva M, Gritti G, Guidetti A, Hitz F, Inghirami G, Ladetto M, Lopez-Guillermo A, Lucchini E, Maiorana A, Marasca R, Matutes E, Meignin V, Merli M, Moccia A, Mollejo M, Montalban C, Novak U, Oscier DG, Passamonti F, Piazza F, Pizzolitto S, Rambaldi A, Sabattini E, Salles G, Santambrogio E, Scarfò L, Stathis A, Stüssi G, Geyer JT, Tapia G, Tarella C, Thieblemont C, Tousseyn T, Tucci A, Vanini G, Visco C, Vitolo U, Walewska R, Zaja F, Zenz T, Zinzani PL, Khiabanian H, Calcinotto A, Bertoni F, Bhagat G, Campo E, De Leval L, Dirnhofer S, Pileri SA, Piris MA, Traverse-Glehen A, Tzankov A, Paulli M, Ponzoni M, Mazzucchelli L, Cavalli F, Zucca E, Rossi D
Blood. 2022 Feb 3;139(5):732-747
Azacytidine and Venetoclax in Relapsed and Refractory Patients With Angioimmunoblastic T-cell Lymphoma.
Laribi K, Baugier de Materre A, Touileb Y, Boursot C, Sandrini J, Cavalieri D, Pastoret C, de Leval L, Tournilhac O
Hemasphere. 2022 Feb;6(2):e675
Romidepsin Plus CHOP Versus CHOP in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Results of the Ro-CHOP Phase III Study (Conducted by LYSA).
Bachy E, Camus V, Thieblemont C, Sibon D, Casasnovas RO, Ysebaert L, Damaj G, Guidez S, Pica GM, Kim WS, Lim ST, André M, García-Sancho AM, Penarrubia MJ, Staber PB, Trotman J, Hüttmann A, Stefoni V, Re A, Gaulard P, Delfau-Larue MH, de Leval L, Meignan M, Li J, Morschhauser F, Delarue R
J Clin Oncol. 2022 Jan 20;40(3):242-251
Prolonged Remissions After Nivolumab Plus Gemcitabine/Oxaliplatin in Relapsed/Refractory T-cell Lymphoma.
Houot R, Poeschel V, Altmann B, Angel S, Thurner L, Illmer T, Andre M, Dreyling M, Maisonneuve H, Tilly H, Mayer S, Casasnovas O, Le Gouill S, Offner F, Cartron G, Kerkhoff A, Weber T, Hoffmann J, Ziepert M, Klapper W, Itti E, Hellwig D, Natchkebia G, de Leval L, Rosenwald A, Haioun C, Dercle L, Gaulard P, Held G
Hemasphere. 2022 Feb;6(2):e672
COVID-19 Pulmonary Pathology: The Experience of European Pulmonary Pathologists throughout the First Two Waves of the Pandemic.
Fortarezza F, Pezzuto F, Hofman P, Kern I, Panizo A, von der Thüsen J, Timofeev S, Gorkiewicz G, Berezowska S, de Leval L, Ortiz-Villalón C, Lunardi F, Calabrese F
Diagnostics (Basel). 2022 Jan 1;12(1)
Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript.
Voruz S, Blum S, de Leval L, Schoumans J, Solly F, Spertini O
Biomark Res. 2021 Dec 20;9(1):92
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.
Favre G, Mazzetti S, Gengler C, Bertelli C, Schneider J, Laubscher B, Capoccia R, Pakniyat F, Ben Jazia I, Eggel-Hort B, de Leval L, Pomar L, Greub G, Baud D, Giannoni E
Viruses. 2021 Dec 15;13(12)
A stone in the bone.
Halfon M, Cochat P, Kissling S, Dattner N, de Leval L, Fakhouri F, Pruijm M, Bonny O
JIMD Rep. 2021 Nov;62(1):6-8
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
Liang HC, Costanza M, Prutsch N, Zimmerman MW, Gurnhofer E, Montes-Mojarro IA, Abraham BJ, Prokoph N, Stoiber S, Tangermann S, Lobello C, Oppelt J, Anagnostopoulos I, Hielscher T, Pervez S, Klapper W, Zammarchi F, Silva DA, Garcia KC, Baker D, Janz M, Schleussner N, Fend F, Pospíšilová Š, Janiková A, Wallwitz J, Stoiber D, Simonitsch-Klupp I, Cerroni L, Pileri S, de Leval L, Sibon D, Fataccioli V, Gaulard P, Assaf C, Knörr F, Damm-Welk C, Woessmann W, Turner SD, Look AT, Mathas S, Kenner L, Merkel O
Nat Commun. 2021 Sep 22;12(1):5577
Hepatosplenic T-cell lymphoma: treatment challenges.
Bron D, De Leval L, Michiels S, Wittnebel S, EuroBloodNet for rare diseases
Curr Opin Oncol. 2021 Sep 1;33(5):406-411
Molecular characterization of Burkitt lymphoma in the breast or ovary.
Elgaafary S, López C, Nagel I, Vater I, Bens S, Szczepanowski M, Aukema SM, Wagener R, Hopp L, Binder H, de Leval L, Klapper W, Siebert R
Leuk Lymphoma. 2021 Sep;62(9):2120-2129
Detection of Gene Fusion Transcripts in Peripheral T-Cell Lymphoma Using a Multiplexed Targeted Sequencing Assay.
Drieux F, Ruminy P, Sater V, Marchand V, Fataccioli V, Lanic MD, Viennot M, Viailly PJ, Sako N, Robe C, Dupuy A, Vallois D, Veresezan L, Poullot E, Picquenot JM, Bossard C, Parrens M, Lemonnier F, Jardin F, de Leval L, Gaulard P
J Mol Diagn. 2021 Aug;23(8):929-940
Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, Switzerland.
Berezowska S, Lefort K, Ioannidou K, Ndiaye DR, Maison D, Petrovas C, Rotman S, Piazzon N, Milowich D, Sala N, Tsai CY, Multone E, Bochud PY, Oddo M, Bisig B, de Leval L
Diagnostics (Basel). 2021 Jul 28;11(8)
CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas.
Monteiro I, Missiaglia E, Sciarra A, Santos JV, Bouilly J, Romero P, Sempoux C, de Leval L
Virchows Arch. 2021 Jul;479(1):209-214
Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming.
Carras S, Chartoire D, Mareschal S, Heiblig M, Marçais A, Robinot R, Urb M, Pommier RM, Julia E, Chebel A, Verney A, Bertheau C, Bardel E, Fezelot C, Courtois L, Lours C, Bouska A, Sharma S, Lefebvre C, Rouault JP, Sibon D, Ferrari A, Iqbal J, de Leval L, Gaulard P, Traverse-Glehen A, Sujobert P, Blery M, Salles G, Walzer T, Bachy E, Genestier L
J Clin Invest. 2021 Jul 1;131(13)
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D
Nat Commun. 2021 Jun 17;12(1):3705
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol. 2021 Jun 1;45(6):773-786
Lymph node involvement by enteropathy-like indolent NK-cell proliferation.
Dargent JL, Tinton N, Trimech M, de Leval L
Virchows Arch. 2021 Jun;478(6):1197-1202
Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine.
Voruz S, de Leval L, Cairoli A
Exp Hematol Oncol. 2021 May 13;10(1):32
A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL.
Schmitz N, Truemper L, Bouabdallah K, Ziepert M, Leclerc M, Cartron G, Jaccard A, Reimer P, Wagner E, Wilhelm M, Sanhes L, Lamy T, de Leval L, Rosenwald A, Roussel M, Kroschinsky F, Lindemann W, Dreger P, Viardot A, Milpied N, Gisselbrecht C, Wulf G, Gyan E, Gaulard P, Bay JO, Glass B, Poeschel V, Damaj G, Sibon D, Delmer A, Bilger K, Banos A, Haenel M, Dreyling M, Metzner B, Keller U, Braulke F, Friedrichs B, Nickelsen M, Altmann B, Tournilhac O
Blood. 2021 May 13;137(19):2646-2656
Case Report: Spontaneous Remission of an Infraorbital Follicular B-Cell Lymphoma: Case Report and Review of the Literature.
Peeters M, Geusens J, Van der Cruyssen F, Michaux L, de Leval L, Tousseyn T, Vandenberghe P, Politis C
Pathol Oncol Res. 2021;27:642433
SARS-CoV-2 ACE-receptor detection in the placenta throughout pregnancy.
Gengler C, Dubruc E, Favre G, Greub G, de Leval L, Baud D
Clin Microbiol Infect. 2021 Mar;27(3):489-490
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Cachot A, Bilous M, Liu YC, Li X, Saillard M, Cenerenti M, Rockinger GA, Wyss T, Guillaume P, Schmidt J, Genolet R, Ercolano G, Protti MP, Reith W, Ioannidou K, de Leval L, Trapani JA, Coukos G, Harari A, Speiser DE, Mathis A, Gfeller D, Altug H, Romero P, Jandus C
Sci Adv. 2021 Feb;7(9)
In Situ Characterization of Follicular Helper CD4 T Cells Using Multiplexed Imaging.
Ioannidou K, Ndiaye DR, Noto A, Fenwick C, Fortis SP, Pantaleo G, Petrovas C, de Leval L
Front Immunol. 2020;11:607626
Integrative analysis of a phase 2 trial combining lenalidomide with CHOP in angioimmunoblastic T-cell lymphoma.
Lemonnier F, Safar V, Beldi-Ferchiou A, Cottereau AS, Bachy E, Cartron G, Fataccioli V, Pelletier L, Robe C, Letourneau A, Missiaglia E, Fourati S, Moles-Moreau MP, Delmer A, Bouabdallah R, Voillat L, Becker S, Bossard C, Parrens M, Casasnovas O, Cacheux V, Régny C, Camus V, Delfau-Larue MH, Meignan M, de Leval L, Gaulard P, Haioun C
Blood Adv. 2021 Jan 26;5(2):539-548
Recent advances upper gastrointestinal lymphomas: molecular updates and diagnostic implications.
Foukas PG, Bisig B, de Leval L
Histopathology. 2021 Jan;78(1):187-214
Chromosomes in breast lymphoma.
de Leval L
Blood. 2020 Dec 17;136(25):2848-2849
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations.
Tomita S, Kikuti YY, Carreras J, Sakai R, Takata K, Yoshino T, Bea S, Campo E, Missiaglia E, Bouilly J, Letourneau A, de Leval L, Nakamura N
Cancers (Basel). 2020 Nov 27;12(12)
Multisystem inflammatory syndrome with refractory cardiogenic shock due to acute myocarditis and mononeuritis multiplex after SARS-CoV-2 infection in an adult.
Othenin-Girard A, Regamey J, Lamoth F, Horisberger A, Glampedakis E, Epiney JB, Kuntzer T, de Leval L, Carballares M, Hurni CA, Rusca M, Pantet O, Di Bernardo S, Oddo M, Comte D, Piquilloud L
Swiss Med Wkly. 2020 Nov 2;150:w20387
MarrowQuant Across Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections.
Tratwal J, Bekri D, Boussema C, Sarkis R, Kunz N, Koliqi T, Rojas-Sutterlin S, Schyrr F, Tavakol DN, Campos V, Scheller EL, Sarro R, Bárcena C, Bisig B, Nardi V, de Leval L, Burri O, Naveiras O
Front Endocrinol (Lausanne). 2020;11:480
Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report.
Salvioni Chiabotti P, Bisig B, Cairoli A, Hajdu SD, Lovey PY, Milowich D, Ziadi S, Du Pasquier R, Brouland JP, de Leval L
Front Oncol. 2020;10:1745
Solute carrier family 12 member 2 as a proteomic and histological biomarker of dysplasia and neoplasia in ulcerative colitis.
Merli AM, Vieujean S, Massot C, Blétard N, Quesada Calvo F, Baiwir D, Mazzucchelli G, Servais L, Wéra O, Oury C, de Leval L, Sempoux C, Manzini R, Bluemel S, Scharl M, Rogler G, De Pauw E, Coimbra Marques C, Colard A, Vijverman A, Delvenne P, Louis E, Meuwis MA
J Crohns Colitis. 2020 Sep 13
Controversies in the Treatment of Peripheral T-cell Lymphoma.
Bachy E, Broccoli A, Dearden C, de Leval L, Gaulard P, Koch R, Morschhauser F, Trümper L, Zinzani PL
Hemasphere. 2020 Oct;4(5):e461
Management of Patients With Hematologic Malignancies During the COVID-19 Pandemic: Practical Considerations and Lessons to Be Learned.
Isidori A, de Leval L, Gergis U, Musto P, Porcu P
Front Oncol. 2020;10:1439
Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract.
Soderquist CR, Patel N, Murty VV, Betman S, Aggarwal N, Young KH, Xerri L, Leeman-Neill R, Lewis SK, Green PH, Hsiao S, Mansukhani MM, Hsi ED, de Leval L, Alobeid B, Bhagat G
Haematologica. 2020 Jul;105(7):1895-1906
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay.
Drieux F, Ruminy P, Abdel-Sater A, Lemonnier F, Viailly PJ, Fataccioli V, Marchand V, Bisig B, Letourneau A, Parrens M, Bossard C, Bruneau J, Dobay P, Veresezan L, Dupuy A, Pujals A, Robe C, Sako N, Copie-Bergman C, Delfau-Larue MH, Picquenot JM, Tilly H, Delarue R, Jardin F, de Leval L, Gaulard P
Haematologica. 2020 Jun;105(6):1582-1592
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma.
Thurner L, Hartmann S, Fadle N, Regitz E, Kemele M, Kim YJ, Bohle RM, Nimmesgern A, von Müller L, Kempf VAJ, Weniger MA, Neumann F, Schneider N, Vornanen M, Sundström C, de Leval L, Engert A, Eichenauer DA, Küppers R, Preuss KD, Hansmann ML, Pfreundschuh M
Nat Commun. 2020 May 18;11(1):2465
Lymphoma Classification.
de Leval L, Jaffe ES
Cancer J. 2020 May/Jun;26(3):176-185
A Diffuse Medullary Hypercaptation With No Bone Lesion.
Christin A, de Leval L, Obeid M
JAMA Oncol. 2020 Feb 1;6(2):291-292
Approach to nodal-based T-cell lymphomas.
de Leval L
Pathology. 2020 Jan;52(1):78-99
Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry.
Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J
Blood. 2019 Dec 12;134(24):2159-2170
Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study.
Aimi F, Procopio MG, Alvarez Flores MT, Brouland JP, Piazzon N, Brajkovic S, Dupouy DG, Gijs M, de Leval L
Virchows Arch. 2019 Sep;475(3):313-323
(18)F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
Jreige M, Letovanec I, Chaba K, Renaud S, Rusakiewicz S, Cristina V, Peters S, Krueger T, de Leval L, Kandalaft LE, Nicod-Lalonde M, Romero P, Prior JO, Coukos G, Schaefer N
Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1859-1868
Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement.
Banga R, Rebecchini C, Procopio FA, Noto A, Munoz O, Ioannidou K, Fenwick C, Ohmiti K, Cavassini M, Corpataux JM, de Leval L, Pantaleo G, Perreau M
PLoS Pathog. 2019 Jul;15(7):e1007918
Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T-cell lymphoma.
Crickx E, Poullot E, Moulis G, Goulabchand R, Fieschi C, Galicier L, Meignin V, Coppo P, Delarue R, Casasnovas O, Roos-Weil D, de Leval L, Parrens M, Michel M, Dupuis J, Le Bras F, Fataccioli V, Martin-Garcia N, Godeau B, Haïoun C, Gaulard P, Mahévas M
Eur J Haematol. 2019 Jul;103(1):35-42
Primary hepatic marginal B cell lymphoma of mucosa-associated lymphoid tissue (MALT) and non-alcoholic steatohepatitis (NASH): more than a coincidence?
Haefliger S, Milowich D, Sciarra A, Trimeche M, Bouilly J, Kaiser J, Volpi S, Brouland JP, Sempoux C, de Leval L
Ann Hematol. 2019 Jun;98(6):1513-1516
Crystal-Storing Histiocytosis.
Rebecchini C, Trimeche M, Rosselet A, de Leval L
Int J Surg Pathol. 2019 Jun;27(4):399-400
Breast implant-associated anaplastic large cell lymphoma and other rare T-cell lymphomas.
de Leval L
Hematol Oncol. 2019 Jun;37 Suppl 1:24-29
Fetal Anthropometric Features: A Postmortem Study of Fetuses After the Termination of Pregnancy for Psychosocial Reasons Between 12 and 20 Gestational Weeks.
Muller Brochut AC, Taffe P, Piaget-Rossel R, de Leval L, Rougemont AL
Pediatr Dev Pathol. 2019 May-Jun;22(3):243-251
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer.
Nguyen HT, Migliozzi D, Bisig B, de Leval L, Gijs MAM
Lab Invest. 2019 May;99(5):722-732
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Heavican TB, Bouska A, Yu J, Lone W, Amador C, Gong Q, Zhang W, Li Y, Dave BJ, Nairismägi ML, Greiner TC, Vose J, Weisenburger DD, Lachel C, Wang C, Fu K, Stevens JM, Lim ST, Ong CK, Gascoyne RD, Missiaglia E, Lemonnier F, Haioun C, Hartmann S, Pedersen MB, Laginestra MA, Wilcox RA, Teh BT, Yoshida N, Ohshima K, Seto M, Rosenwald A, Ott G, Campo E, Rimsza LM, Jaffe ES, Braziel RM, d'Amore F, Inghirami G, Bertoni F, de Leval L, Gaulard P, Staudt LM, McKeithan TW, Pileri S, Chan WC, Iqbal J
Blood. 2019 Apr 11;133(15):1664-1676
Correction to: CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Sciarra A, Monteiro I, Ménétrier-Caux C, Caux C, Gilbert B, Halkic N, La Rosa S, Romero P, Sempoux C, de Leval L
Cancer Immunol Immunother. 2019 Mar;68(3):529
CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Sciarra A, Monteiro I, Ménétrier-Caux C, Caux C, Gilbert B, Halkic N, La Rosa S, Romero P, Sempoux C, de Leval L
Cancer Immunol Immunother. 2019 Mar;68(3):467-478
CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.
Martín-Garcia D, Navarro A, Valdés-Mas R, Clot G, Gutiérrez-Abril J, Prieto M, Ribera-Cortada I, Woroniecka R, Rymkiewicz G, Bens S, de Leval L, Rosenwald A, Ferry JA, Hsi ED, Fu K, Delabie J, Weisenburger D, de Jong D, Climent F, O'Connor SJ, Swerdlow SH, Torrents D, Beltran S, Espinet B, González-Farré B, Veloza L, Costa D, Matutes E, Siebert R, Ott G, Quintanilla-Martinez L, Jaffe ES, López-Otín C, Salaverria I, Puente XS, Campo E, Beà S
Blood. 2019 Feb 28;133(9):940-951
Cyclin D1-positive Mediastinal Large B-Cell Lymphoma With Copy Number Gains of CCND1 Gene: A Study of 3 Cases With Nonmediastinal Disease.
Chen BJ, Ruminy P, Roth CG, Bisig B, Mankel B, Steinhilber J, Bohers E, Jardin F, Fend F, Swerdlow SH, Copie-Bergman C, de Leval L, Quintanilla-Martinez L
Am J Surg Pathol. 2019 Jan;43(1):110-120
The Need for a Consensus Next-generation Sequencing Panel for Mature Lymphoid Malignancies.
Sujobert P, Le Bris Y, de Leval L, Gros A, Merlio JP, Pastoret C, Huet S, Sarkozy C, Davi F, Callanan M, Thieblemont C, Sibon D, Asnafi V, Preudhomme C, Gaulard P, Jardin F, Salles G, Macintyre E
Hemasphere. 2019 Feb;3(1):e169
IG-MYC (+) neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.
Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R
Blood. 2018 Nov 22;132(21):2280-2285
Advancing synoptic cancer reports beyond English: the University of Bern/PathoLink approach.
Banz Y, Berezowska S, de Leval L, Rubbia-Brandt L, Tolnay M, Moch H, Perren A, Hewer E
Virchows Arch. 2018 Nov;473(5):655-656
Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma.
Letourneau A, Maerevoet M, Milowich D, Dewind R, Bisig B, Missiaglia E, de Leval L
Virchows Arch. 2018 Oct;473(4):505-511
New insights in the pathogenesis of T-cell lymphomas.
Lemonnier F, Gaulard P, de Leval L
Curr Opin Oncol. 2018 Sep;30(5):277-284
Multiple Ways to Detect IDH2 Mutations in Angioimmunoblastic T-Cell Lymphoma from Immunohistochemistry to Next-Generation Sequencing.
Dupuy A, Lemonnier F, Fataccioli V, Martin-Garcia N, Robe C, Pelletier R, Poullot E, Moktefi A, Mokhtari K, Rousselet MC, Traverse-Glehen A, Delarue R, Tournilhac O, Delfau-Larue MH, Haioun C, Ortonne N, Copie-Bergman C, de Leval L, Pujals A, Gaulard P
J Mol Diagn. 2018 Sep;20(5):677-685
RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells.
Vallois D, Dupuy A, Lemonnier F, Allen G, Missiaglia E, Fataccioli V, Ortonne N, Clavert A, Delarue R, Rousselet MC, Fabiani B, Llamas-Gutierrez F, Ogawa S, Thome M, Ko YH, Kataoka K, Gaulard P, de Leval L
Haematologica. 2018 Aug;103(8):e360-e363
CD73 expression and clinical significance in human metastatic melanoma.
Monteiro I, Vigano S, Faouzi M, Treilleux I, Michielin O, Ménétrier-Caux C, Caux C, Romero P, de Leval L
Oncotarget. 2018 Jun 1;9(42):26659-26669
A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.
Herfs M, Roncarati P, Koopmansch B, Peulen O, Bruyere D, Lebeau A, Hendrick E, Hubert P, Poncin A, Penny W, Piazzon N, Monnien F, Guenat D, Mougin C, Prétet JL, Vuitton L, Segers K, Lambert F, Bours V, de Leval L, Valmary-Degano S, Quick CM, Crum CP, Delvenne P
Br J Cancer. 2018 May;118(10):1302-1312
Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland.
Steiner R, Kridel R, Giostra E, McKee T, Achermann R, Mueller N, Manuel O, Dickenmann M, Schuurmans MM, de Leval L, Fehr T, Tinguely M, Binet I, Cogliatti S, Haralamvieva E, Koller M, The Swiss Transplant Cohort Study Stcs, Dietrich PY
Swiss Med Wkly. 2018;148:w14596
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma".
Voruz S, Martins F, Cairoli A, Naveiras O, Homicsko K, Missiaglia E, de Leval L, Bisig B, Michielin O, Blum S
Haematologica. 2018 Mar;103(3):e130
AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress.
Kfoury A, Armaro M, Collodet C, Sordet-Dessimoz J, Giner MP, Christen S, Moco S, Leleu M, de Leval L, Koch U, Trumpp A, Sakamoto K, Beermann F, Radtke F
EMBO J. 2018 Mar 1;37(5)
Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.
Lemonnier F, Poullot E, Dupuy A, Couronné L, Martin N, Scourzic L, Fataccioli V, Bruneau J, Cairns RA, Mak TW, Bernard OA, de Leval L, Gaulard P
Haematologica. 2018 Mar;103(3):e115-e118
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma.
Voruz S, Cairoli A, Naveiras O, de Leval L, Missiaglia E, Homicsko K, Michielin O, Blum S
Haematologica. 2018 Jan;103(1):e39-e41
Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation.
Van Hede D, Polese B, Humblet C, Wilharm A, Renoux V, Dortu E, de Leval L, Delvenne P, Desmet CJ, Bureau F, Vermijlen D, Jacobs N
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9056-E9065
B-cell lymphomas with discordance between pathological features and clinical behavior.
de Leval L, Copie-Bergman C, Rosenwald A, Rimsza L, Pittaluga S, Bisig B, Dirnhofer S, Facchetti F, Pileri S, Fend F, Wotherspoon A
Virchows Arch. 2017 Oct;471(4):439-451
Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.
Facchetti F, Pileri SA, Lorenzi L, Tabanelli V, Rimsza L, Pittaluga S, Dirnhofer S, Copie-Bergman C, de Leval L, Rosenwald A, Wotherspoon A, Fend F
Virchows Arch. 2017 Oct;471(4):467-489
Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.
Broglie MA, Stoeckli SJ, Sauter R, Pasche P, Reinhard A, de Leval L, Huber GF, Pezier TF, Soltermann A, Giger R, Arnold A, Dettmer M, Arnoux A, Müller M, Spreitzer S, Lang F, Lutchmaya M, Stauffer E, Espeli V, Martucci F, Bongiovanni M, Foerbs D, Jochum W
Head Neck. 2017 Oct;39(10):2004-2015
The clinicopathologic spectrum of mature aggressive B cell lymphomas.
Rimsza L, Pittaluga S, Dirnhofer S, Copie-Bergman C, de Leval L, Facchetti F, Pileri S, Rosenwald A, Wotherspoon A, Fend F
Virchows Arch. 2017 Oct;471(4):453-466
Microfluidics for rapid cytokeratin immunohistochemical staining in frozen sections.
Brajkovic S, Dupouy DG, de Leval L, Gijs MA
Lab Invest. 2017 Aug;97(8):983-991
Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy.
Darcis G, Van der Auwera G, Giot JB, Hayette MP, Tassin F, Arrese Estrada J, Cnops L, Moutschen M, de Leval L, Leonard P
BMC Infect Dis. 2017 Jul 7;17(1):478
Very low expression of PD-L1 in medullary thyroid carcinoma.
Bongiovanni M, Rebecchini C, Saglietti C, Bulliard JL, Marino L, de Leval L, Sykiotis GP
Endocr Relat Cancer. 2017 Jun;24(6):L35-L38
Immunoregulation of Dendritic Cell Subsets by Inhibitory Receptors in Urothelial Cancer.
Chevalier MF, Bohner P, Pieraerts C, Lhermitte B, Gourmaud J, Nobile A, Rotman S, Cesson V, Martin V, Legris AS, Dartiguenave F, Gharbi D, De Leval L, Speiser DE, Nardelli-Haefliger D, Jichlinski P, Derré L
Eur Urol. 2017 Jun;71(6):854-857
[Molecular oncogenesis of lymphomas: role of the SETD2 gene in intestinal T-cell lymphomas].
Vallois D, Roberti A, Bisig B, Gaulard P, de Leval L
Med Sci (Paris). 2017 May;33(5):469-473
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Ehx G, Fransolet G, de Leval L, D'Hondt S, Lucas S, Hannon M, Delens L, Dubois S, Drion P, Beguin Y, Humblet-Baron S, Baron F
Oncoimmunology. 2017;6(5):e1314425
The Genetic Basis of Hepatosplenic T-cell Lymphoma.
McKinney M, Moffitt AB, Gaulard P, Travert M, De Leval L, Nicolae A, Raffeld M, Jaffe ES, Pittaluga S, Xi L, Heavican T, Iqbal J, Belhadj K, Delfau-Larue MH, Fataccioli V, Czader MB, Lossos IS, Chapman-Fredricks JR, Richards KL, Fedoriw Y, Ondrejka SL, Hsi ED, Low L, Weisenburger D, Chan WC, Mehta-Shah N, Horwitz S, Bernal-Mizrachi L, Flowers CR, Beaven AW, Parihar M, Baseggio L, Parrens M, Moreau A, Sujobert P, Pilichowska M, Evens AM, Chadburn A, Au-Yeung RK, Srivastava G, Choi WW, Goodlad JR, Aurer I, Basic-Kinda S, Gascoyne RD, Davis NS, Li G, Zhang J, Rajagopalan D, Reddy A, Love C, Levy S, Zhuang Y, Datta J, Dunson DB, Davé SS
Cancer Discov. 2017 Apr;7(4):369-379
Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin.
Dobay MP, Lemonnier F, Missiaglia E, Bastard C, Vallois D, Jais JP, Scourzic L, Dupuy A, Fataccioli V, Pujals A, Parrens M, Le Bras F, Rousset T, Picquenot JM, Martin N, Haioun C, Delarue R, Bernard OA, Delorenzi M, de Leval L, Gaulard P
Haematologica. 2017 Apr;102(4):e148-e151
IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis.
Bruls S, Courtois A, Delvenne P, Hustinx R, Moutschen M, De Leval L, Defraigne JO, Sakalihasan N
Ann Thorac Surg. 2017 Mar;103(3):e239-e240
Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation.
Boyer DF, McKelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittaluga S, Ferry JA, Harris NL, Sohani AR
Am J Surg Pathol. 2017 Mar;41(3):299-312
How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
Schmitz N, de Leval L
Br J Haematol. 2017 Mar;176(6):851-866
Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment in breast cancer.
Nguyen HT, Trouillon R, Matsuoka S, Fiche M, de Leval L, Bisig B, Gijs MA
Lab Invest. 2017 Jan;97(1):93-103
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
Lemonnier F, Cairns RA, Inoue S, Li WY, Dupuy A, Broutin S, Martin N, Fataccioli V, Pelletier R, Wakeham A, Snow BE, de Leval L, Pujals A, Haioun C, Paci A, Tobin ER, Narayanaswamy R, Yen K, Jin S, Gaulard P, Mak TW
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15084-15089
Cutaneous presentation of hepatosplenic T-cell lymphoma-a potential mimicker of primary cutaneous gamma-delta T-cell lymphoma.
Karpate A, Barcena C, Hohl D, Bisig B, de Leval L
Virchows Arch. 2016 Nov;469(5):591-596
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Vallois D, Dobay MP, Morin RD, Lemonnier F, Missiaglia E, Juilland M, Iwaszkiewicz J, Fataccioli V, Bisig B, Roberti A, Grewal J, Bruneau J, Fabiani B, Martin A, Bonnet C, Michielin O, Jais JP, Figeac M, Bernard OA, Delorenzi M, Haioun C, Tournilhac O, Thome M, Gascoyne RD, Gaulard P, de Leval L
Blood. 2016 Sep 15;128(11):1490-502
Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.
Roberti A, Dobay MP, Bisig B, Vallois D, Boéchat C, Lanitis E, Bouchindhomme B, Parrens MC, Bossard C, Quintanilla-Martinez L, Missiaglia E, Gaulard P, de Leval L
Nat Commun. 2016 Sep 7;7:12602
PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals.
Banga R, Procopio FA, Noto A, Pollakis G, Cavassini M, Ohmiti K, Corpataux JM, de Leval L, Pantaleo G, Perreau M
Nat Med. 2016 Jul;22(7):754-61
Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer.
Dupouy DG, Ciftlik AT, Fiche M, Heintze D, Bisig B, de Leval L, Gijs MA
Sci Rep. 2016 Feb 9;6:20277
ALK-negative anaplastic large-cell lymphoma.
Gaulard P, de Leval L
Blood. 2016 Jan 14;127(2):175-7
Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Vijgen S, Wyss C, Meylan P, Bisig B, Letovanec I, Manuel O, Pascual M, de Leval L
Transplantation. 2016 Jan;100(1):134-40
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.
Ribera-Cortada I, Martinez D, Amador V, Royo C, Navarro A, Beà S, Gine E, de Leval L, Serrano S, Wotherspoon A, Colomer D, Martinez A, Campo E
Mod Pathol. 2015 Nov;28(11):1435-47
Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets.
de Leval L, Parrens M, Le Bras F, Jais JP, Fataccioli V, Martin A, Lamant L, Delarue R, Berger F, Arbion F, Bossard C, Copin MC, Canioni D, Charlotte F, Damaj G, Dartigues P, Fabiani B, Ledoux-Pilon A, Montagne K, Molina T, Patey M, Tas P, Peoch M, Petit B, Petrella T, Picquenot JM, Rousset T, Rousselet MC, Soubeyran I, Thiebault S, Tournilhac O, Xerri L, Gisselbrecht C, Haioun C, Delsol G, Gaulard P
Haematologica. 2015 Sep;100(9):e361-4
Lymphocytic variant hypereosinophilic syndrome progressing to angioimmunoblastic T-cell lymphoma.
Roufosse F, de Leval L, van Krieken H, van Deuren M
Leuk Lymphoma. 2015 Jun;56(6):1891-4
Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.
Geyer JT, Subramaniyam S, Jiang Y, Elemento O, Ferry JA, de Leval L, Nakashima MO, Liu YC, Martin P, Mathew S, Orazi A, Tam W
Hum Pathol. 2015 Feb;46(2):260-71
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Küçük C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W, Lack N, Alkan C, Williams JC, Avery KN, Kavak P, Scuto A, Sen E, Gaulard P, Staudt L, Iqbal J, Zhang W, Cornish A, Gong Q, Yang Q, Sun H, d'Amore F, Leppä S, Liu W, Fu K, de Leval L, McKeithan T, Chan WC
Nat Commun. 2015 Jan 14;6:6025
Recent advances in intestinal lymphomas.
Foukas PG, de Leval L
Histopathology. 2015 Jan;66(1):112-36
Primary γδ T cell lymphoma of the lung: report of a case with features suggesting derivation from intraepithelial γδ T lymphocytes.
Choe JY, Bisig B, de Leval L, Jeon YK
Virchows Arch. 2014 Dec;465(6):731-6
Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels.
Bossard C, Dobay MP, Parrens M, Lamant L, Missiaglia E, Haioun C, Martin A, Fabiani B, Delarue R, Tournilhac O, Delorenzi M, Gaulard P, de Leval L
Blood. 2014 Nov 6;124(19):2983-6
Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies.
Swerdlow SH, Jaffe ES, Brousset P, Chan JK, de Leval L, Gaulard P, Harris NL, Pileri S, Weiss LM, International Lymphoma Study Group
Am J Surg Pathol. 2014 Oct;38(10):e60-71
Accuracy of sentinel lymph node dissection for melanoma staging in the presence of a collision tumour with a lymphoproliferative disease.
Gero D, Queiros da Mota V, Boubaker A, Berthod G, de Leval L, Demartines N, Matter M
Melanoma Res. 2014 Aug;24(4):371-6
Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.
Somja J, Bisig B, Bonnet C, Herens C, Siebert R, de Leval L
Virchows Arch. 2014 Jun;464(6):735-41
Cellular origin of T-cell lymphomas.
de Leval L, Gaulard P
Blood. 2014 May 8;123(19):2909-10
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM, Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood. 2014 May 8;123(19):2915-23
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD
J Thorac Oncol. 2014 May;9(5):596-611
Conjunctival MALT lymphoma: utility of FDG PET/CT for diagnosis, staging, and evaluation of treatment response.
Sallak A, Besson FL, Pomoni A, Christinat A, Adler M, Aegerter JP, Nguyen C, de Leval L, Frossard V, Prior JO
Clin Nucl Med. 2014 Mar;39(3):295-7
Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma.
Kuonen F, Bucher M, de Leval L, Vernez M, Gilliet M, Conrad C, Feldmeyer L
Case Rep Dermatol. 2014 Jan;6(1):37-42
The microenvironment in T-cell lymphomas: emerging themes.
Gaulard P, de Leval L
Semin Cancer Biol. 2014 Feb;24:49-60
Pathology of peripheral T-cell lymphomas: where do we stand?
Gaulard P, de Leval L
Semin Hematol. 2014 Jan;51(1):5-16
CD30-positive peripheral T-cell lymphomas share molecular and phenotypic features.
Bisig B, de Reyniès A, Bonnet C, Sujobert P, Rickman DS, Marafioti T, Delsol G, Lamant L, Gaulard P, de Leval L
Haematologica. 2013 Aug;98(8):1250-8
Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas.
Martin-Guerrero I, Salaverria I, Burkhardt B, Szczepanowski M, Baudis M, Bens S, de Leval L, Garcia-Orad A, Horn H, Lisfeld J, Pellissery S, Klapper W, Oschlies I, Siebert R
Haematologica. 2013 Aug;98(8):1237-41
ROQUIN/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma.
Auguste T, Travert M, Tarte K, Amé-Thomas P, Artchounin C, Martin-Garcia N, de Reynies A, de Leval L, Gaulard P, Delfau-Larue MH
PLoS One. 2013;8(6):e64536
VIII. New markers in peripheral T-cell lymphomas: more entities or more confusion?
Gaulard P, de Leval L
Hematol Oncol. 2013 Jun;31 Suppl 1:51-6
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia.
Courville EL, Wu Y, Kourda J, Roth CG, Brockmann J, Muzikansky A, Fathi AT, de Leval L, Orazi A, Hasserjian RP
Mod Pathol. 2013 Jun;26(6):751-61
Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve.
Roumy A, de Leval L, Niclauss L, Schaefer SC, Kurtin P, Dogan A, von Segesser LK, Ruchat P
Ann Thorac Surg. 2013 May;95(5):1782-4
Molecular underpinning of extranodal NK/T-cell lymphoma.
Huang Y, de Leval L, Gaulard P
Best Pract Res Clin Haematol. 2013 Mar;26(1):57-74
Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease.
Bruck F, Belle L, Lechanteur C, de Leval L, Hannon M, Dubois S, Castermans E, Humblet-Baron S, Rahmouni S, Beguin Y, Briquet A, Baron F
Cytotherapy. 2013 Mar;15(3):267-79
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production.
Perreau M, Savoye AL, De Crignis E, Corpataux JM, Cubas R, Haddad EK, De Leval L, Graziosi C, Pantaleo G
J Exp Med. 2013 Jan 14;210(1):143-56
EBV+ cutaneous B-cell lymphoproliferation of the leg in an elderly patient with mycosis fungoides and methotrexate treatment.
Rausch T, Cairoli A, Benhattar J, Spring P, Hohl D, de Leval L
APMIS. 2013 Jan;121(1):79-84
Infliximab therapy for a severe case of IgG4-related ocular adnexal disorder recalcitrant to corticosteroid treatment.
Balaskas K, de Leval L, La Corte R, Zografos L, Guex-Crosier Y
Ocul Immunol Inflamm. 2012 Dec;20(6):478-80
Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma.
Valleron W, Ysebaert L, Berquet L, Fataccioli V, Quelen C, Martin A, Parrens M, Lamant L, de Leval L, Gisselbrecht C, Gaulard P, Brousset P
Blood. 2012 Nov 8;120(19):3997-4005
Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics.
Moroch J, Copie-Bergman C, de Leval L, Plonquet A, Martin-Garcia N, Delfau-Larue MH, Molinier-Frenkel V, Belhadj K, Haioun C, Audouin J, Swerdlow SH, Marafioti T, Gaulard P
Am J Surg Pathol. 2012 Nov;36(11):1636-46
Targeting intratumoral B cells with rituximab in addition to CHOP in angioimmunoblastic T-cell lymphoma. A clinicobiological study of the GELA.
Delfau-Larue MH, de Leval L, Joly B, Plonquet A, Challine D, Parrens M, Delmer A, Salles G, Morschhauser F, Delarue R, Brice P, Bouabdallah R, Casasnovas O, Tilly H, Gaulard P, Haioun C
Haematologica. 2012 Oct;97(10):1594-602
The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index.
Slotta-Huspenina J, Koch I, de Leval L, Keller G, Klier M, Bink K, Kremer M, Raffeld M, Fend F, Quintanilla-Martinez L
Haematologica. 2012 Sep;97(9):1422-30
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.
Lemonnier F, Couronné L, Parrens M, Jaïs JP, Travert M, Lamant L, Tournillac O, Rousset T, Fabiani B, Cairns RA, Mak T, Bastard C, Bernard OA, de Leval L, Gaulard P
Blood. 2012 Aug 16;120(7):1466-9
Interpretation of needle biopsies of the kidney for investigation of renal masses.
Lhermitte B, de Leval L
Virchows Arch. 2012 Jul;461(1):13-26
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets.
Travert M, Huang Y, de Leval L, Martin-Garcia N, Delfau-Larue MH, Berger F, Bosq J, Brière J, Soulier J, Macintyre E, Marafioti T, de Reyniès A, Gaulard P
Blood. 2012 Jun 14;119(24):5795-806
An unusual uterine tumor with signet ring cell features.
Sarro R, Fiche M, Bisig B, Ketterer N, Benhattar J, Achtari C, de Leval L
Int J Gynecol Pathol. 2012 May;31(3):236-41
Lymphoproliferative disorders associated with hypereosinophilia.
Roufosse F, Garaud S, de Leval L
Semin Hematol. 2012 Apr;49(2):138-48
BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas.
Yan Q, Huang Y, Watkins AJ, Kocialkowski S, Zeng N, Hamoudi RA, Isaacson PG, de Leval L, Wotherspoon A, Du MQ
Haematologica. 2012 Apr;97(4):595-8
New biomarkers in T-cell lymphomas.
Bisig B, Gaulard P, de Leval L
Best Pract Res Clin Haematol. 2012 Mar;25(1):13-28
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.
Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW
Blood. 2012 Feb 23;119(8):1901-3
An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma.
Watkins AJ, Hamoudi RA, Zeng N, Yan Q, Huang Y, Liu H, Zhang J, Braggio E, Fonseca R, de Leval L, Isaacson PG, Wotherspoon A, McPhail ED, Dogan A, Du MQ
PLoS One. 2012;7(9):e44997
An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rγnull mice allows HIV replication and development of anti-HIV immune responses.
Singh M, Singh P, Gaudray G, Musumeci L, Thielen C, Vaira D, Vandergeeten C, Delacroix L, Van Gulck E, Vanham G, de Leval L, Rahmouni S, Moutschen M
PLoS One. 2012;7(6):e38491
c-Maf expression in angioimmunoblastic T-cell lymphoma reflects follicular helper T-cell derivation rather than oncogenesis.
Bisig B, Thielen C, Herens C, Gofflot S, Travert M, Delfau-Larue MH, Boniver J, Gaulard P, de Leval L
Histopathology. 2012 Jan;60(2):371-6
PRDM1 is a tumor suppressor gene in natural killer cell malignancies.
Küçük C, Iqbal J, Hu X, Gaulard P, De Leval L, Srivastava G, Au WY, McKeithan TW, Chan WC
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20119-24
Tricky and terrible T-cell tumors: these are thrilling times for testing: molecular pathology of peripheral T-cell lymphomas.
de Leval L, Gaulard P
Hematology Am Soc Hematol Educ Program. 2011;2011:336-43
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