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- Pathologie clinique
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- Dre Bettina Bisig
Dre Bettina Bisig
Dre Bettina Bisig
Médecin associée
Service de pathologie clinique
Institut universitaire de pathologie
Bugnon 25
CH-1011 Lausanne
Tél. +41 21 314 7790
Fax: +41 21 314 7115
Contact e-mail
Publications
Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology.
Christinat Y, Hamelin B, Alborelli I, Angelino P, Barbié V, Bisig B, Dawson H, Frattini M, Grob T, Jochum W, Nienhold R, McKee T, Matter M, Missiaglia E, Molinari F, Rothschild S, Sobottka-Brillout AB, Vassella E, Zoche M, Mertz KD
Virchows Arch. 2024 Dec;485(6):1033-1039
Clinical use of circulating tumor DNA analysis in patients with lymphoma.
Bisig B, Lefort K, Carras S, de Leval L
Hum Pathol. 2024 Nov 2:105679
Primary diffuse large B-cell lymphoma of the central nervous system identified with CSF biomarkers.
Loser V, Segot A, de Leval L, Bisig B, Brouland JP, Hewer E, Barcena C, Hottinger AF, Pot C
BMC Neurol. 2024 Jul 22;24(1):250
Methylation-Based Characterization of a New IDH2 Mutation in Sinonasal Undifferentiated Carcinoma.
Burgermeister S, Stoykova S, Krebs FS, Zoete V, Mbefo M, Egervari K, Reinhard A, Bisig B, Hewer E
Int J Mol Sci. 2024 Jun 13;25(12)
Cytokine-pathway blockers worsen mycosis fungoides masquerading as psoriasis.
Blanchard G, Bisig B, de Leval L, Hohl D, Guenova E
JAAD Case Rep. 2024 Jun;48:98-102
Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases.
Sarro R, Bisig B, Guey B, Missiaglia E, Cairoli A, Omoumi P, Letovanec I, Ferry JA, Hasserjian RP, de Leval L
Mod Pathol. 2024 Apr;37(4):100440
Angioimmunoblastic T-cell lymphoma and Kaposi sarcoma: A fortuitous collision?
Poullot E, Milowich D, Lemonnier F, Bisig B, Robe C, Pelletier L, Letourneau A, Dupuy A, Sako N, Ketterer N, Carde P, Dartigues P, Delfau-Larue MH, de Leval L, Gaulard P
Histopathology. 2024 Feb;84(3):556-564
Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma - morphology, molecular characteristics and differential diagnosis.
Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology. 2024 Jan;84(1):32-49
Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient.
Anchisi S, Wolfer A, Bisig B, Missiglia E, Tiab A, Kamel EM, Michielin O, Coukos G, Homicsko K
Cancer Biol Ther. 2023 Dec 31;24(1):2193116
What is new in the classification of peripheral T cell lymphomas?
de Leval L, Bisig B
Pathologie (Heidelb). 2023 Dec;44(Suppl 3):128-135
Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions.
Bisig B, Savage KJ, De Leval L
Haematologica. 2023 Dec 1;108(12):3227-3243
ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study.
Sibon D, Bisig B, Bonnet C, Poullot E, Bachy E, Cavalieri D, Fataccioli V, Bregnard C, Drieux F, Bruneau J, Lemonnier F, Dupuy A, Bossard C, Parrens M, Bouabdallah K, Ketterer N, Berthod G, Cairoli A, Damaj G, Tournilhac O, Jais JP, Gaulard P, De Leval L
Haematologica. 2023 Jun 1;108(6):1590-1603
MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology.
Sarkis R, Burri O, Royer-Chardon C, Schyrr F, Blum S, Costanza M, Cherix S, Piazzon N, Barcena C, Bisig B, Nardi V, Sarro R, Ambrosini G, Weigert M, Spertini O, Blum S, Deplancke B, Seitz A, de Leval L, Naveiras O
Mod Pathol. 2023 Apr;36(4):100088
Response and Resistance to Trametinib in MAP2K1-Mutant Triple-Negative Melanoma.
Krebs FS, Moura B, Missiaglia E, Aedo-Lopez V, Michielin O, Tsantoulis P, Bisig B, Trimech M, Zoete V, Homicsko K
Int J Mol Sci. 2023 Feb 24;24(5)
Perioperative Management of a Patient With Combined Bernard Soulier syndrome and Storage Pool Disease During On-Pump Cardiac Surgery.
Christophel-Plathier E, Costanza M, Kirsch M, Dulguerov F, Chapuis-Bernasconi C, Bisig B, Verdy F, Mendes V, Rancati V, Alberio L, Marcucci C, Scala E
J Cardiothorac Vasc Anesth. 2023 Jan;37(1):90-95
Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.
Veloza L, Cavalieri D, Missiaglia E, Ledoux-Pilon A, Bisig B, Pereira B, Bonnet C, Poullot E, Quintanilla-Martinez L, Dubois R, Llamas-Gutierrez F, Bossard C, De Wind R, Drieux F, Fontaine J, Parrens M, Sandrini J, Fataccioli V, Delfau-Larue MH, Daniel A, Lhomme F, Clément-Filliatre L, Lemonnier F, Cairoli A, Morel P, Glaisner S, Joly B, El Yamani A, Laribi K, Bachy E, Siebert R, Vallois D, Gaulard P, Tournilhac O, De Leval L
Haematologica. 2023 Jan 1;108(1):181-195
HHV8-negative primary effusion-based large B-cell lymphoma in a patient with chronic myeloid leukemia, BCR::ABL1-positive under dasatinib treatment: Report of a new case and literature review.
Christe L, Veloza L, Gros L, Bisig B, Blum S, Hewer E, de Leval L
Diagn Cytopathol. 2022 Dec;50(12):E351-E356
Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.
Bisig B, Cairoli A, Gaide O, Somja J, Bregnard C, Gaulard P, Xerri L, Lefort K, Missiaglia E, Gilliet M, Hohl D, Guenova E, de Leval L
Virchows Arch. 2022 Oct;481(4):653-657
Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations.
Nicolae A, Bouilly J, Lara D, Fataccioli V, Lemonnier F, Drieux F, Parrens M, Robe C, Poullot E, Bisig B, Bossard C, Letourneau A, Missiaglia E, Bonnet C, Szablewski V, Traverse-Glehen A, Delfau-Larue MH, de Leval L, Gaulard P
Mod Pathol. 2022 Aug;35(8):1126-1136
EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disor
Veloza L, Tsai CY, Bisig B, Pantet O, Alberio L, Sempoux C, Cavassini M, de Leval L
Virchows Arch. 2022 Mar;480(3):699-705
Isolated skin infiltration by a blastic plasmacytoid dendritic cell neoplasm.
Stalder G, Milowich D, Blum S, Schoumans J, Bisig B, Spertini O
EJHaem. 2022 Feb;3(1):259-260
Postmortem Cardiopulmonary Pathology in Patients with COVID-19 Infection: Single-Center Report of 12 Autopsies from Lausanne, Switzerland.
Berezowska S, Lefort K, Ioannidou K, Ndiaye DR, Maison D, Petrovas C, Rotman S, Piazzon N, Milowich D, Sala N, Tsai CY, Multone E, Bochud PY, Oddo M, Bisig B, de Leval L
Diagnostics (Basel). 2021 Jul 28;11(8)
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol. 2021 Jun 1;45(6):773-786
[Anaplastic thyroid carcinoma : new therapeutic approaches].
Stamatiou A, Herrera-Gómez RG, Szturz P, Bisig B, Romano E, Sykiotis G, Gorostidi F, La Rosa S, Kopp P, Cristina V
Rev Med Suisse. 2021 May 19;17(739):962-966
Recent advances upper gastrointestinal lymphomas: molecular updates and diagnostic implications.
Foukas PG, Bisig B, de Leval L
Histopathology. 2021 Jan;78(1):187-214
Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology.
Krebs FS, Gérard C, Wicky A, Aedo-Lopez V, Missiaglia E, Bisig B, Trimech M, Michielin O, Homicsko K, Zoete V
Int J Mol Sci. 2020 Oct 28;21(21)
MarrowQuant Across Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections.
Tratwal J, Bekri D, Boussema C, Sarkis R, Kunz N, Koliqi T, Rojas-Sutterlin S, Schyrr F, Tavakol DN, Campos V, Scheller EL, Sarro R, Bárcena C, Bisig B, Nardi V, de Leval L, Burri O, Naveiras O
Front Endocrinol (Lausanne). 2020;11:480
Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report.
Salvioni Chiabotti P, Bisig B, Cairoli A, Hajdu SD, Lovey PY, Milowich D, Ziadi S, Du Pasquier R, Brouland JP, de Leval L
Front Oncol. 2020;10:1745
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay.
Drieux F, Ruminy P, Abdel-Sater A, Lemonnier F, Viailly PJ, Fataccioli V, Marchand V, Bisig B, Letourneau A, Parrens M, Bossard C, Bruneau J, Dobay P, Veresezan L, Dupuy A, Pujals A, Robe C, Sako N, Copie-Bergman C, Delfau-Larue MH, Picquenot JM, Tilly H, Delarue R, Jardin F, de Leval L, Gaulard P
Haematologica. 2020 Jun;105(6):1582-1592
Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma.
Bongiovanni M, Sykiotis GP, La Rosa S, Bisig B, Trimech M, Missiaglia E, Gremaud M, Salvatori Chappuis V, De Vito C, Sciarra A, Foulkes WD, Pusztaszeri M
Thyroid. 2020 Jan;30(1):72-80
Deep Response to Anti-PD-1 Therapy of Metastatic Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumor With CD274/PD-L1 Amplification.
Özdemir BC, Bohanes P, Bisig B, Missiaglia E, Tsantoulis P, Coukos G, Montemurro M, Homicsko K, Michielin O
JCO Precis Oncol. 2019 Dec;3:1-6
Acinar cell carcinoma of the pancreas with thyroid-like follicular features: first description of a new diagnostic challenging subtype.
Saglietti C, Schneider V, Bongiovanni M, Missiaglia E, Bisig B, Dorta G, Demartines N, Sempoux C, La Rosa S
Virchows Arch. 2019 Dec;475(6):789-794
Consistency and reproducibility of next-generation sequencing in cytopathology: A second worldwide ring trial study on improved cytological molecular reference specimens.
Pisapia P, Malapelle U, Roma G, Saddar S, Zheng Q, Pepe F, Bruzzese D, Vigliar E, Bellevicine C, Luthra R, Nikiforov YE, Mayo-de-Las-Casas C, Molina-Vila MA, Rosell R, Bihl M, Savic S, Bubendorf L, de Biase D, Tallini G, Hwang DH, Sholl LM, Vander Borght S, Weynand B, Stieber D, Vielh P, Rappa A, Barberis M, Fassan M, Rugge M, De Andrea CE, Lozano MD, Lupi C, Fontanini G, Schmitt F, Dumur CI, Bisig B, Bongiovanni M, Merkelbach-Bruse S, Büttner R, Nikiforova MN, Roy-Chowdhuri S, Troncone G, Molecular Cytopathology Meeting Group
Cancer Cytopathol. 2019 May;127(5):285-296
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer.
Nguyen HT, Migliozzi D, Bisig B, de Leval L, Gijs MAM
Lab Invest. 2019 May;99(5):722-732
Cyclin D1-positive Mediastinal Large B-Cell Lymphoma With Copy Number Gains of CCND1 Gene: A Study of 3 Cases With Nonmediastinal Disease.
Chen BJ, Ruminy P, Roth CG, Bisig B, Mankel B, Steinhilber J, Bohers E, Jardin F, Fend F, Swerdlow SH, Copie-Bergman C, de Leval L, Quintanilla-Martinez L
Am J Surg Pathol. 2019 Jan;43(1):110-120
Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma.
Letourneau A, Maerevoet M, Milowich D, Dewind R, Bisig B, Missiaglia E, de Leval L
Virchows Arch. 2018 Oct;473(4):505-511
[Liquid biopsy, a new opportunity for personalized oncology].
Astaras C, Dolcan A, Bisig B, Zaman K
Rev Med Suisse. 2018 May 16;14(607):1028-1032
The Bethesda System for Reporting Thyroid Cytopathology Explained for Practitioners: Frequently Asked Questions.
Bongiovanni M, Papadakis GE, Rouiller N, Marino L, Lamine F, Bisig B, Ziadi S, Sykiotis GP
Thyroid. 2018 May;28(5):556-565
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma".
Voruz S, Martins F, Cairoli A, Naveiras O, Homicsko K, Missiaglia E, de Leval L, Bisig B, Michielin O, Blum S
Haematologica. 2018 Mar;103(3):e130
Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.
Saldarriaga J, Bisig B, Couchy G, Castain C, Zucman-Rossi J, Balabaud C, Sempoux C, Bioulac-Sage P
Histopathology. 2017 Dec;71(6):989-993
B-cell lymphomas with discordance between pathological features and clinical behavior.
de Leval L, Copie-Bergman C, Rosenwald A, Rimsza L, Pittaluga S, Bisig B, Dirnhofer S, Facchetti F, Pileri S, Fend F, Wotherspoon A
Virchows Arch. 2017 Oct;471(4):439-451
[Molecular oncogenesis of lymphomas: role of the SETD2 gene in intestinal T-cell lymphomas].
Vallois D, Roberti A, Bisig B, Gaulard P, de Leval L
Med Sci (Paris). 2017 May;33(5):469-473
Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.
Sempoux C, Bisig B, Couchy G, Balabaud C, Zucman-Rossi J, Bioulac-Sage P
Hum Pathol. 2017 Apr;62:122-125
Gray platelet syndrome: Novel mutations of the NBEAL2 gene.
Bottega R, Nicchia E, Alfano C, Glembotsky AC, Pastore A, Bertaggia-Calderara D, Bisig B, Duchosal MA, Arbesú G, Alberio L, Heller PG, Savoia A
Am J Hematol. 2017 Feb;92(2):E20-E22
Papillary thyroid carcinoma with nodular fasciitis-like stroma and β-catenin mutations should be renamed papillary thyroid carcinoma with desmoid-type fibromatosis.
Rebecchini C, Nobile A, Piana S, Sarro R, Bisig B, Gerasimos SP, Saglietti C, Matter M, Marino L, Bongiovanni M
Mod Pathol. 2017 Feb;30(2):236-245
Microfluidics-assisted fluorescence in situ hybridization for advantageous human epidermal growth factor receptor 2 assessment in breast cancer.
Nguyen HT, Trouillon R, Matsuoka S, Fiche M, de Leval L, Bisig B, Gijs MA
Lab Invest. 2017 Jan;97(1):93-103
Cutaneous presentation of hepatosplenic T-cell lymphoma-a potential mimicker of primary cutaneous gamma-delta T-cell lymphoma.
Karpate A, Barcena C, Hohl D, Bisig B, de Leval L
Virchows Arch. 2016 Nov;469(5):591-596
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.
Vallois D, Dobay MP, Morin RD, Lemonnier F, Missiaglia E, Juilland M, Iwaszkiewicz J, Fataccioli V, Bisig B, Roberti A, Grewal J, Bruneau J, Fabiani B, Martin A, Bonnet C, Michielin O, Jais JP, Figeac M, Bernard OA, Delorenzi M, Haioun C, Tournilhac O, Thome M, Gascoyne RD, Gaulard P, de Leval L
Blood. 2016 Sep 15;128(11):1490-502
Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.
Roberti A, Dobay MP, Bisig B, Vallois D, Boéchat C, Lanitis E, Bouchindhomme B, Parrens MC, Bossard C, Quintanilla-Martinez L, Missiaglia E, Gaulard P, de Leval L
Nat Commun. 2016 Sep 7;7:12602
Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer.
Dupouy DG, Ciftlik AT, Fiche M, Heintze D, Bisig B, de Leval L, Gijs MA
Sci Rep. 2016 Feb 9;6:20277
Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Vijgen S, Wyss C, Meylan P, Bisig B, Letovanec I, Manuel O, Pascual M, de Leval L
Transplantation. 2016 Jan;100(1):134-40
Primary γδ T cell lymphoma of the lung: report of a case with features suggesting derivation from intraepithelial γδ T lymphocytes.
Choe JY, Bisig B, de Leval L, Jeon YK
Virchows Arch. 2014 Dec;465(6):731-6
Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.
Somja J, Bisig B, Bonnet C, Herens C, Siebert R, de Leval L
Virchows Arch. 2014 Jun;464(6):735-41
Does introduction of thresholds in decision aids benefit the patient?: Comparison between findings-based and threshold-based diagnostic decision aids.
Bisig B, Moreira J, Combes M, Asiimwe A, Bisoffi Z, Haegeman F, Bottieau E, Van den Ende J
Med Decis Making. 2012 Nov-Dec;32(6):E16-34
An unusual uterine tumor with signet ring cell features.
Sarro R, Fiche M, Bisig B, Ketterer N, Benhattar J, Achtari C, de Leval L
Int J Gynecol Pathol. 2012 May;31(3):236-41
Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.
Dejeans N, Glorieux C, Guenin S, Beck R, Sid B, Rousseau R, Bisig B, Delvenne P, Buc Calderon P, Verrax J
Free Radic Biol Med. 2012 Mar 15;52(6):993-1002
New biomarkers in T-cell lymphomas.
Bisig B, Gaulard P, de Leval L
Best Pract Res Clin Haematol. 2012 Mar;25(1):13-28
Is increasing complexity of algorithms the price for higher accuracy? virtual comparison of three algorithms for tertiary level management of chronic cough in people living with HIV in a low-income country.
Mukabatsinda C, Nguyen J, Bisig B, Lynen L, Coppens YD, Asiimwe A, Van den Ende J
BMC Med Inform Decis Mak. 2012 Jan 19;12:2
c-Maf expression in angioimmunoblastic T-cell lymphoma reflects follicular helper T-cell derivation rather than oncogenesis.
Bisig B, Thielen C, Herens C, Gofflot S, Travert M, Delfau-Larue MH, Boniver J, Gaulard P, de Leval L
Histopathology. 2012 Jan;60(2):371-6
Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion.
Renoux VM, Bisig B, Langers I, Dortu E, Clémenceau B, Thiry M, Deroanne C, Colige A, Boniver J, Delvenne P, Jacobs N
Eur J Immunol. 2011 Nov;41(11):3240-52
Primary central nervous system lymphoma in a patient treated with natalizumab.
Phan-Ba R, Bisig B, Deprez M, De Prijck B, Delrue G, Herens C, Moonen G, Belachew S, de Leval L
Ann Neurol. 2011 Jun;69(6):1060-1; author reply 1061-2
CHIC cells: a novel ALK+ cell line derived from a relapsed anaplastic large cell lymphoma.
Thielen C, Bisig B, Gofflot S, Herens C, Fillet G, Jamar M, Tassin F, Boniver J, Drion P, de Leval L
Br J Haematol. 2011 Feb;152(3):356-60
Molecular classification of T-cell lymphomas.
de Leval L, Bisig B, Thielen C, Boniver J, Gaulard P
Crit Rev Oncol Hematol. 2009 Nov;72(2):125-43
Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
Bisig B, Copie-Bergman C, Baia M, Gaulard P, Delbecque K, Fassotte MF, Boniver J, de Leval L
Hum Pathol. 2009 Oct;40(10):1504-9
Weighing harm in therapeutic decisions of smear-negative pulmonary tuberculosis.
Moreira J, Bisig B, Muwawenimana P, Basinga P, Bisoffi Z, Haegeman F, Kishore P, Van den Ende J
Med Decis Making. 2009 May-Jun;29(3):380-90
Rue du Bugnon 25
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 7111
Rue du Bugnon 25
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 7111