Blood Cancer Proteostasis

Our team investigates protein homeostasis, or “proteostasis”, in blood cancer cells. Proteostasis is a prerequisite for the functioning of cells and requires a finely tuned regulation of protein synthesis and degradation. This tightly controlled balance maintains the cellular proteome, the set of proteins in a cell, which is often disrupted in cancer. By understanding how proteostasis mechanisms in cancer cells differ from those in healthy cells, we can identify vulnerabilities in cancer cells that can be targeted by new therapies.

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Understanding proteostasis in blood cancer cells: our team investigates how differences in protein synthesis and degradation in cancer cells can be exploited for therapeutic purposes.